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Antibiotic identified by AI Computational approaches are emerging as powerful tools for the discovery of antibiotics. A study now uses machine learning to discover abaucin, a potent antibiotic that targets the bacterial pathogen Acinetobacter baumannii.
a, Machine learning methods enable swift exploration of chemical space, enhancing the likelihood of discovering new compounds with antibacterial activity. Liu et al.11 used a message-passing neural network to predict activity against A. baumannii for compounds from the Drug Repurposing Hub. b, Abaucin was identified as an antibacterial compound with narrow-spectrum activity. This compound was shown to disrupt lipoprotein trafficking via LolE, a functionally conserved protein responsible for transferring lipoproteins from the inner to the outer membrane. Abaucin was shown to be effective at controlling an A. baumannii infection in a mouse wound model.
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